Recombinant Antigens

HIV1 gp41o

HIV1 gp41o
AGHIV1o
1Product overview
Protein type
 recombinant Ag
Application
 Lateral flow, ELSA, Western blot
2Product specification
HostEscherichia coli
Purity
 > 95%
Molcular weight
30kDa
Form/Buffer
 Liquid/10mM Carbonate buffer, 0.1% sodiumazide(NaN3), pH9.6
Concentration
 > 3.0mg/ml
3Storage & Safety
Storage

* Short term storage : Store at 4℃ 

* Long term storage : Aliquot and store at below -20℃

* Avoid repeated freeze/thaw cycles.

4General information
Note

HIV-1 group O was named for “Outlier” group.

After the discovery of the virus ANT70 by a group in Belgium(1990), and the further characterization of this isolate, as well as the MVP5180 and VAU isolates(1994) it became clear that a new group of viruses, distinct from the HIV-1 Major (M) group, was present in the human population. 


HIV-1 group O patient's sera were only reactive to the Group O-specific V3 and gp41 peptides. This provided the first direct evidence that this patient was infected with a Group O variant.


Gp41, known as glycoprotein 41, is a subunit of the envelope protein complex of retroviruses which includes human immunodefiiciency (HIV). 


Gp41 is transmembrane protein that contains several sites within its ectodomain that are required for infection of host cells. 


Due to its importance in host cell infection, it has also gained much attention as a potential target for HIV serological test for diagnosis.